Cichoric Acid Ameliorates Monosodium Urate-Induced Inflammatory Response by Reducing NLRP3 Inflammasome Activation via Inhibition of NF-kB Signaling Pathway

Gouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased concentrations. Here, we elucidated role natural compound cichoric acid (CA) on MSU crystal-stimulated inflammatory response. The THP-1-derived macrophages (THP-Ms) were pretreated with CA then stimulated suspensions. protein levels p65 I?B?, activation NF-?B signaling pathway measuring expression its downstream cytokines, activity NLRP3 inflammasome measured western blotting ELISA. treatment markedly inhibited degradation I?B? reduced genes such as IL-1?, TNF-?, COX-2, PGE2 in MSU-stimulated THP-M cells. Therefore, infer that effectively alleviated MSU-induced inflammation suppressing thereby reducing inflammasome. These results suggest could be a novel therapeutic strategy averting acute episodes gout.